CFTR and chaperones

  title={CFTR and chaperones},
  author={Margarida D Amaral},
  journal={Journal of Molecular Neuroscience},
The autosomal recessive disease cystic fibrosis (CF) is caused by mutations in the gene coding for the CF transmembrane conductance regulator (CFTR) protein, a cAMP-activated chloride channel expressed at the apical membrane of epithelial cells. Although about 1000 different mutations have been identified, most CF patients carry the F508del mutation in at… CONTINUE READING