CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells

@inproceedings{Edlund2014CFTRAA,
  title={CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells},
  author={Anna K Edlund and Jonathan Lou S. Esguerra and Anna Wendt and Malin Flodstr{\"o}m-Tullberg and Lena Eliasson},
  booktitle={BMC medicine},
  year={2014}
}
BACKGROUND Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene lead to the disease cystic fibrosis (CF). Although patients with CF often have disturbances in glucose metabolism including impaired insulin release, no previous studies have tested the hypothesis that CFTR has a biological function in pancreatic beta-cells. METHODS Experiments were performed on islets and single beta-cells from human donors and NMRI-mice. Detection of CFTR was investigated using PCR… CONTINUE READING