CFTR (ABCC7) is a hydrolyzable-ligand-gated channel

Abstract

As the product of the gene mutated in cystic fibrosis, the most common genetic disease of Caucasians, CFTR is an atypical ABC protein. From an evolutionary perspective, it is apparently a relatively young member of the ABC family, present only in metazoans where it plays a critical role in epithelial salt and fluid homeostasis. Functionally, the membrane… (More)
DOI: 10.1007/s00424-006-0140-z

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