CFTR: interacting with everything?

@article{Kunzelmann2001CFTRIW,
  title={CFTR: interacting with everything?},
  author={Karl Kunzelmann},
  journal={News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society},
  year={2001},
  volume={16},
  pages={167-70}
}
  • Karl Kunzelmann
  • Published 2001 in
    News in physiological sciences : an international…
More than 1,300 different mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) are the cause for cystic fibrosis. CFTR is in charge of proper secretion and absorption of electrolytes, and thus the disease is characterized by defective epithelial Cl(-) secretion and enhanced Na(+) absorption. Recent studies show that CFTR interacts with other proteins via PDZ domains. 

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Activation of the epithelial Na + channel ( ENaC ) requires CFTR Cl  channel function

MM Reddy, PM Quinton
Nature • 1999

CFTR, A Regulator of Channels

The Journal of Membrane Biology • 1999

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