CFTR: domains, structure, and function.

  title={CFTR: domains, structure, and function.},
  author={Shreenivas Devidas and William B Guggino},
  journal={Journal of bioenergetics and biomembranes},
  volume={29 5},
Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis (CF) (Collins, 1992). Over 500 naturally occurring mutations have been identified in CF gene which are located in all of the domains of the protein (Kerem et al., 1990; Mercier et al., 1993; Ghanem et al., 1994; Fanen et al., 1992; Ferec et al., 1992; Cutting et al., 1990). Early studies by several investigators characterized CFTR as a chloride channel (Anderson et al.; 1991b,c… CONTINUE READING
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