CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis.

@article{Hegyi2016CFTRAN,
  title={CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis.},
  author={P{\'e}ter Hegyi and Michael Wilschanski and Shmuel Muallem and Gergely L Lukacs and Mikl{\'o}s Sahin-T{\'o}th and Aliye Uc and Michael A. Gray and Zolt{\'a}n Rakonczay and Jozsef Maleth},
  journal={Reviews of physiology, biochemistry and pharmacology},
  year={2016},
  volume={170},
  pages={
          37-66
        }
}
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel that conducts chloride and bicarbonate ions across epithelial cell membranes. Mutations in the CFTR gene diminish the ion channel function and lead to impaired epithelial fluid transport in multiple organs such as the lung and the pancreas resulting in cystic fibrosis. Heterozygous carriers of CFTR mutations do not develop cystic fibrosis but exhibit increased risk for pancreatitis and associated pancreatic damage… CONTINUE READING
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