• Corpus ID: 37321628

CFS : Inflammation , Immune Function , and Neuroendocrine Interactions Klimas and Koneru

  title={CFS : Inflammation , Immune Function , and Neuroendocrine Interactions Klimas and Koneru},
  author={Nancy Klimas and Anne O'Brien Koneru},
Investigations into the underlying cause of chronic fatigue syndrome have advanced the field considerably in the past year. Gene microarray data have led to a better understanding of pathogenesis. Recent research has evaluated genetic signatures, described biologic subgroups, and suggested potential targeted treatments. Acute viral infection studies found that initial infection severity was the single best predictor of persistent fatigue. Genomic studies showed that persistent cases express… 



Immunologic abnormalities in chronic fatigue syndrome

The patterns of immune marker abnormalities observed was compatible with a chronic viral reactivation syndrome and there were significant differences between patients with CFS and controls.

Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments

A collaborative study group has been formed to develop an understanding of the molecular pathogenesis of CFS, to develop a diagnostic test and to develop specific and curative treatments, and novel treatments that are important to trial in patients with CFS are interferon-β and one of the anti-tumour necrosis factor-α drugs.

Preliminary evidence of mitochondrial dysfunction associated with post-infective fatigue after acute infection with Epstein Barr Virus

Preliminary data provide insights into alterations in gene transcripts associated with the varied clinical outcomes from acute infectious mononucleosis, including fatty acid metabolism and the cell cycle.

Chronic fatigue syndrome is associated with diminished intracellular perforin

There was an indication of a reduced perforin level within the cytotoxic T cells of CFS subjects, providing the first evidence, to the authors' knowledge, to suggest a T cell associated cytotoxicity deficit in CFS.

Infection and vaccination in chronic fatigue syndrome: Myth or reality?

A working group of the Canadian Laboratory Center for Disease Control that was founded in order to examine the suspected association between CFS and vaccinations concluded that there is no evidence that relates CFS to vaccination.

Azithromycin in Chronic Fatigue Syndrome (CFS), an analysis of clinical data

The efficacy of azithromycin in the responsive patients could be explained by the modulating effect on a chronic primed state of the immune cells of the brain, or the activated peripheral immune system.

Clinical activity of folinic acid in patients with chronic fatigue syndrome.

The findings provide unprecedented evidence that CFS frequently is a folinic acid responsive clinical entity accompanied by B-cell immunodeficiency and inappropriate antibody responses to EBV.

Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach

A significant subset of CFS patients may have a chronic, disseminated, non-cytolytic form of enteroviral infection, which could be diagnosed by stomach biopsy, and this work has shown that stomach biopsies taken from patients at the onset of the CFS/abdominal symptoms, and 2–8 years later showed positive staining in the paired specimens.

Studies on enterovirus in patients with chronic fatigue syndrome.

It was concluded that it is unlikely that persistent enterovirus infection plays a pathogenetic role in CFS, although an effect in initiating the disease process cannot be excluded.