CFP1 interacts with DNMT1 independently of association with the Setd1 Histone H3K4 methyltransferase complexes.

@article{Butler2008CFP1IW,
  title={CFP1 interacts with DNMT1 independently of association with the Setd1 Histone H3K4 methyltransferase complexes.},
  author={Jill Sergesketter Butler and Jeong-Heon Lee and David G. Skalnik},
  journal={DNA and cell biology},
  year={2008},
  volume={27 10},
  pages={
          533-43
        }
}
CXXC finger protein 1 (CFP1) is a component of the Setd1A and Setd1B methyltransferase complexes, localizes to euchromatic regions of the genome, and specifically binds unmethylated CpG dinucleotides in DNA. Murine embryos lacking CFP1 exhibit peri-implantation lethality, a developmental time that correlates with global epigenetic reprogramming. CFP1-deficient embryonic stem (ES) cells exhibit a 70% reduction in global cytosine methylation and a 60% decrease in maintenance DNA methyltransferase… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex

  • Lee, J.-H, C. M. Tate, You, J.-S, D. G. Skalnik
  • J Biol Chem 282,
  • 2007
Highly Influential
18 Excerpts

High conservation

  • A. Roguev, D. Schaft, A. Shevchenko, R. Aasland, A. F. Stewart
  • 2003
Highly Influential
4 Excerpts

Identification and characterization of the DNA binding domain of CpG-binding protein

  • Lee, J.-H, K. S. Voo, D. G. Skalnik
  • J Biol Chem
  • 2001
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…