CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.

  title={CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.},
  author={Babet van der Vaart and Wilhelmina E. van Riel and Harinath Doodhi and Josta T. Kevenaar and Eugene A. Katrukha and Laura F. Gumy and Benjamin Pierre Bouchet and Ilya Grigoriev and Samantha A. Spangler and Ka Lou Yu and Phebe S. Wulf and Jingchao Wu and Gideon W A Lansbergen and Eljo Y van Battum and R Jeroen Pasterkamp and Yuko Mimori-Kiyosue and Jeroen A A Demmers and Natacha Olieric and Ivan V. Maly and Casper C Hoogenraad and Anna Akhmanova},
  journal={Developmental cell},
  volume={27 2},
Mechanisms controlling microtubule dynamics at the cell cortex play a crucial role in cell morphogenesis and neuronal development. Here, we identified kinesin-4 KIF21A as an inhibitor of microtubule growth at the cell cortex. In vitro, KIF21A suppresses microtubule growth and inhibits catastrophes. In cells, KIF21A restricts microtubule growth and participates in organizing microtubule arrays at the cell edge. KIF21A is recruited to the cortex by KANK1, which coclusters with liprin-α1/β1 and… CONTINUE READING
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  • S. A. Spangler, D. Jaarsma, E. De Graaff, P. S. Wulf, A. Akhmanova, C. C. Hoogenraad
  • J Comp Neurol 519, 3040-3060.
  • 2011
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