CETP inhibitors and cardiovascular disease: Time to think again

  title={CETP inhibitors and cardiovascular disease: Time to think again},
  author={Norman E. Miller and Cesare R. Sirtori and Gerald F. M. Watts},
Inhibition of cholesteryl ester transfer protein (CETP) lowers plasma low-density lipoprotein cholesterol concentration and raises high-density lipoprotein (HDL) cholesterol, suggesting it might prevent cardiovascular disease (CVD). From the outset, however, the concept has been controversial owing to uncertainty about its effects on HDL function and reverse cholesterol transport (RCT). Although there has long been good evidence that CETP inhibition reduces atherosclerosis in rabbits, the first… CONTINUE READING
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