CEREBROSPINAL FLUID (CSF) IL-17A, IL-17F, IL-34 AND CXCL-13 LEVELS IN AMYOTROPHIC LATERAL SCLEROSIS (ALS/MND) PATIENTS

@article{SoytrkOrallar2019CEREBROSPINALF,
  title={CEREBROSPINAL FLUID (CSF) IL-17A, IL-17F, IL-34 AND CXCL-13 LEVELS IN AMYOTROPHIC LATERAL SCLEROSIS (ALS/MND) PATIENTS},
  author={Hayriye Soyt{\"u}rk Orallar and Şeyda a Karab{\"o}cek and Bihter G{\"o}kçe G{\"o}kçe Bozat and Şule Aydın T{\"u}rkoğlu},
  journal={E-journal of New World Sciences Academy},
  year={2019}
}
In this study, our clinic follow-up ALS/MND diagnose the cerebrospinal fluid of patients (CSF), IL-17A, IL-17F, IL-34 cytokines and CXCL-13 chemokine to evaluate the levels. that were determined by ELISA. In our study, significantly higher in the patient group and the proinflammatory cytokine, IL-17A and IL-17F of endothelial cells, fibroblasts and also known to be expressed in neurones. However, CXCL-13 level is considered among the patient group and the control group was not statistically… Expand

References

SHOWING 1-10 OF 55 REFERENCES
IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients
TLDR
Immune modulation of chronic inflammation may be a new approach to sALS by inducing in mononuclear cells the cytokines inducing chronic inflammation in sALS spinal cord, in particular IL-6 and IL-17A, damaging neurons. Expand
Increased levels of interleukins 2 and 17 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension.
TLDR
It is concluded that IIH is associated with elevated levels of IL-17 and IL-2 in the CSF, suggesting the involvement of these cytokines in disease pathogenesis. Expand
Update on interleukin-17: a role in the pathogenesis of inflammatory arthritis and implication for clinical practice
TLDR
The present review describes the key molecules of the IL-17 pathway, which are or could be targeted for treatment, and the pathogenesis of such possible adverse events is analysed. Expand
Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis
TLDR
Results not only strengthen the clinical evidence that neurodegenerative diseases are accompanied by the increased inflammatory response, but also reveal the unique inflammatory response profile in the central nervous system of patients with AD, PD and ALS. Expand
Interleukin‐17‐producing γδ T (γδ17) cells in inflammatory diseases
TLDR
Recent knowledge about the pathophysiological function of γδ17 cells in infection and inflammatory diseases and therapeutic advances targeting IL‐17 are discussed. Expand
Increased IL-17, a Pathogenic Link between Hepatosplenic Schistosomiasis and Amyotrophic Lateral Sclerosis: A Hypothesis
TLDR
It is hypothesized that the factors that might have led to increased IL-17 in the hepatosplenic schistosomiasis mansoni might also have contributed to the development of amyotrophic lateral sclerosis in the described patient. Expand
Targeting CXCL13 During Neuroinflammation.
TLDR
This review focuses on how CXCL13 contributes to the pathogenesis of selected CNS disorders involving both experimental animals and humans, paying particular attention to the issue of whether (and if so, how) blockade of this ligand or its receptor might benefit the host. Expand
Amyotrophic lateral sclerosis: Amino acid levels in plasma and cerebrospinal fluid
TLDR
The findings do not lend support to the hypothesis that the sporadic form of ALS results from overexcitation of motor neurons by excitatory amino acids, and concentrations of glutamate, aspartate, and glycine were normal in the CSF of all 17 patients examined. Expand
Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury.
TLDR
A biochemical model was established using S100beta, GFAP, and IL-8 to predict injury severity (ASIA A, B, or C) and segmental motor recovery at 6 months post injury was better predicted by these CSF proteins than with the patients' baseline ASIA grade. Expand
Interleukin‐34, a comprehensive review
TLDR
One decade after its discovery, IL‐34 has been introduced as a newcomer to the big family of interleukins with specific physiological functions, critical pathological roles, and promising clinical applications in disease diagnosis and treatment. Expand
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