CEREBRAL UPTAKE OF DRUGS IN HUMANS

@article{Upton2007CEREBRALUO,
  title={CEREBRAL UPTAKE OF DRUGS IN HUMANS},
  author={Richard N Upton},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2007},
  volume={34}
}
  • R. Upton
  • Published 1 August 2007
  • Biology, Medicine
  • Clinical and Experimental Pharmacology and Physiology
1 Drugs that target the central nervous system (CNS) are under‐represented in the pharmacopoeia because of the difficulties of overcoming passive and active defences of the blood–brain barrier (BBB). Methods have been developed in drug discovery to make decisions about whether a compound crosses the BBB. Less is known about how the rate and extent of CNS penetration of a drug affects its clinical behaviour, largely because of past difficulties in measuring the cerebral uptake of drugs in humans… 
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