CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly.

@article{GmezFerrera2012CEP192IP,
  title={CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly.},
  author={Mar{\'i}a Ana G{\'o}mez-Ferrer{\'i}a and Mikhail Bashkurov and Michael Mullin and Anne-Claude Gingras and Laurence Pelletier},
  journal={Cell cycle},
  year={2012},
  volume={11 19},
  pages={3555-8}
}
CEP192 is a centrosome protein that plays a critical role in centrosome biogenesis and function in mammals, Drosophila and C. elegans. Moreover, CEP192-depleted cells arrest in mitosis with disorganized microtubules, suggesting that CEP192's function in spindle assembly goes beyond its role in centrosome activity and pointing to a potentially more direct role in the regulation of the mitotic microtubule landscape. To better understand CEP192 function in mitosis, we used mass spectrometry to… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

The X-linked deubiquitinase USP9X is an integral component of centrosome.

The Journal of biological chemistry • 2017
View 1 Excerpt

Similar Papers

Loading similar papers…