CENP-T provides a structural platform for outer kinetochore assembly.

  title={CENP-T provides a structural platform for outer kinetochore assembly.},
  author={Tatsuya Nishino and Florencia Rago and Tetsuya Hori and Kentaro Tomii and Iain M Cheeseman and Tatsuo Fukagawa},
  journal={The EMBO journal},
  volume={32 3},
The kinetochore forms a dynamic interface with microtubules from the mitotic spindle during mitosis. The Ndc80 complex acts as the key microtubule-binding complex at kinetochores. However, it is unclear how the Ndc80 complex associates with the inner kinetochore proteins that assemble upon centromeric chromatin. Here, based on a high-resolution structural analysis, we demonstrate that the N-terminal region of vertebrate CENP-T interacts with the 'RWD' domain in the Spc24/25 portion of the Ndc80… CONTINUE READING
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