CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold

@article{Nishino2012CENPTWSXFA,
  title={CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold},
  author={Tatsuya Nishino and Kozo Takeuchi and Karen E. Gascoigne and Aussie Suzuki and Tetsuya Hori and Takuji Oyama and Kosuke Morikawa and Iain M Cheeseman and Tatsuo Fukagawa},
  journal={Cell},
  year={2012},
  volume={148},
  pages={487-501}
}
The multiprotein kinetochore complex must assemble at a specific site on each chromosome to achieve accurate chromosome segregation. Defining the nature of the DNA-protein interactions that specify the position of the kinetochore and provide a scaffold for kinetochore formation remain key goals. Here, we demonstrate that the centromeric histone-fold-containing CENP-T-W and CENP-S-X complexes coassemble to form a stable CENP-T-W-S-X heterotetramer. High-resolution structural analysis of the… CONTINUE READING
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