CENP-C is necessary but not sufficient to induce formation of a functional centromere.

@article{Fukagawa1999CENPCIN,
  title={CENP-C is necessary but not sufficient to induce formation of a functional centromere.},
  author={Takako Fukagawa and Carlos Pend{\'o}n and Joanne Morris and William Wesley Brown},
  journal={The EMBO journal},
  year={1999},
  volume={18 15},
  pages={4196-209}
}
CENP-C is an evolutionarily conserved centromeric protein. We have used the chicken DT40 cell line to test the idea that CENP-C is sufficient as well as necessary for the formation of a functional centromere. We have compared the effects of disrupting the localization of CENP-C with those of inducibly overexpressing the protein. Removing CENP-C from the centromere causes disassembly of the centromere protein complex and blocks cells at the metaphase-anaphase junction. Overexpressed CENP-C is… CONTINUE READING

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