CENP-B is a highly conserved mammalian centromere protein with homology to the helix-loop-helix family of proteins

@article{Sullivan1991CENPBIA,
  title={CENP-B is a highly conserved mammalian centromere protein with homology to the helix-loop-helix family of proteins},
  author={Kevin F. Sullivan and Charles A. Glass},
  journal={Chromosoma},
  year={1991},
  volume={100},
  pages={360-370}
}
CENP-B is a centromere associated protein originally identified in human cells as an 80 kDa autoantigen recognized by sera from patients with anti-centromere antibodies (ACA). Recent evidence indicates that CENP-B interacts with centromeric heterochromatin in human chromosomes and may bind to a specific subset of human alphoid satellite DNA. CENP-B has not been unambiguously identified in non-primates and could, in principal, be a primate-specific alphoid DNA binding protein. In this work, a… CONTINUE READING

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