CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses.

Abstract

Cellular senescence is an irreversible growth arrest and is presumed to be a natural barrier to tumor development. Like telomere shortening, certain defects in chromosome integrity can trigger senescence; however, the roles of centromere proteins in regulating commitment to the senescent state remains to be established. We examined chromatin structure in… (More)
DOI: 10.1128/MCB.01318-09

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@article{Maehara2010CENPARI, title={CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses.}, author={Kayoko Maehara and Kohta Takahashi and Shigeaki Saitoh}, journal={Molecular and cellular biology}, year={2010}, volume={30 9}, pages={2090-104} }