CELLULAR IMMUNOLOGY 141,211-218 (1992) Induction of Cytotoxic T Lymphocytes in Mice against the Principal Neutralizing Domain of HIV-1 by Immunization with an Engineered T-Cytotoxic-T-Helper Synthetic Peptide Construct

  • Published 2003


Peptide constructs were engineered by colinear synthesis of two short synthetic peptide determinants: a determinant recognized by T helper cells (TD,) and a determinant recognized by T cytotoxic cells (TD,). Three types of constructs were synthesized: TD,-TDr, , TD,-TD, , and TD,,KK-TD,, where KK are two lysine residues. In vivo immunization with free… (More)


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