CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics

  title={CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics},
  author={Ke-Tai Guo and Angela Paul and Christian Schichor and Gerhard Ziemer and Hans P. Wendel},
  journal={International Journal of Molecular Sciences},
  pages={668 - 678}
Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis… CONTINUE READING