CED-12/ELMO, a Novel Member of the CrkII/Dock180/Rac Pathway, Is Required for Phagocytosis and Cell Migration

@article{Gumienny2001CED12ELMOAN,
  title={CED-12/ELMO, a Novel Member of the CrkII/Dock180/Rac Pathway, Is Required for Phagocytosis and Cell Migration},
  author={Tina L. Gumienny and Enrico Brugnera and Annie-Carole Tosello-Trampont and Jason Michael Kinchen and Lisa B. Haney and Kiyoji Nishiwaki and Scott F. Walk and Michael E Nemergut and Ian G. Macara and Ross Francis and Tim Schedl and Yi Qin and Linda van Aelst and Michael O. Hengartner and Kodi S. Ravichandran},
  journal={Cell},
  year={2001},
  volume={107},
  pages={27-41}
}

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It is proposed that CED-2/CrkII and Ced-5/DOCK180 function to activate CED -10/Rac in a GTPase signalling pathway that controls the polarized extension of cell surfaces.
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CED-2/CrkII and CED-10/Rac are part of an evolutionarily conserved pathway in engulfment of apoptotic cells, which is consistent with genetic studies in the worm that place ced-10 downstream ofced-2 (crk) in cell corpse removal.
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
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This work reports that ced-5, a gene required for cell-corpse engulfment in the nematode Caenorhabditis elegans, encodes a protein that is similar to the human protein DOCK180 and the Drosophila melanogaster protein Myoblast City, both of which have been implicated in the extension of cell surfaces.
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The αvβ5 receptor mediates both binding and internalization of apoptotic cells and is linked to the CrkII–Dock180–Rac1 molecular complex in mammalian cells, revealing an evolutionarily conserved signalling pathway that is responsible for the recognition and internalized of apoptosis by both professional and non-professional phagocytes.
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CAS/Crk assembly serves as a “molecular switch” for the induction of cell migration and appears to contribute to the invasive property of tumors.
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Results suggest that Mbc is a specific upstream regulator of Rac activity that mediates several morphogenetic processes in Drosophila embryogenesis.
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