CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans

@article{Zhou2001CED1IA,
  title={CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans},
  author={Zheng Zhou and Erika A. Hartwieg and H Robert Horvitz},
  journal={Cell},
  year={2001},
  volume={104},
  pages={43-56}
}
We cloned the C. elegans gene ced-1, which is required for the engulfment of cells undergoing programmed cell death. ced-1 encodes a transmembrane protein similar to human SREC (Scavenger Receptor from Endothelial Cells). We showed that ced-1 is expressed in and functions in engulfing cells. The CED-1 protein localizes to cell membranes and clusters around neighboring cell corpses. CED-1 failed to cluster around cell corpses in mutants defective in the engulfment gene ced-7. Motifs in the… CONTINUE READING
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