CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans

  title={CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans},
  author={Zheng Zhou and Erika A. Hartwieg and H Robert Horvitz},
We cloned the C. elegans gene ced-1, which is required for the engulfment of cells undergoing programmed cell death. ced-1 encodes a transmembrane protein similar to human SREC (Scavenger Receptor from Endothelial Cells). We showed that ced-1 is expressed in and functions in engulfing cells. The CED-1 protein localizes to cell membranes and clusters around neighboring cell corpses. CED-1 failed to cluster around cell corpses in mutants defective in the engulfment gene ced-7. Motifs in the… CONTINUE READING
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of Caenorhabditis elegans

  • I. D. Campbell, P. Bork
  • 1993
Highly Influential
4 Excerpts

The C

  • Y. Wu, H. R. Horvitz
  • elegans cell corpse engulfment gene ced-7 encodes…
  • 1998
Highly Influential
5 Excerpts

The role of phosphatidylserine in recognition of apo - 1977 ) . To count persistent germ cell corpses , we scored one gonadal ptotic cells by phagocytes

  • P. M. Horvitz
  • Cell Death Diff .
  • 1998
Highly Influential
6 Excerpts

Morphology of programmed cell death in the ventral nerve cord of Caenorhabditis elegans larvae

  • A.M.G. Robertson, J. N. Thomson
  • J. Embryol. Exp. Morph. 67, 89–100.
  • 1982
Highly Influential
6 Excerpts

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