CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L.

@article{Banting2005CECR2AP,
  title={CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L.},
  author={Graham S. Banting and Orr Barak and Tanya M Ames and Amanda C Burnham and Melanie D. Kardel and Neil S Cooch and Courtney E Davidson and Roseline Godbout and H. E. McDermid and Ramin Shiekhattar},
  journal={Human molecular genetics},
  year={2005},
  volume={14 4},
  pages={513-24}
}
Chromatin remodeling complexes play critical roles in development. Here we describe a transcription factor, CECR2, which is involved in neurulation and chromatin remodeling. CECR2 shows complex alternative splicing, but all variants contain DDT and bromodomain motifs. A mutant mouse line was generated from an embryonic stem cell line containing a genetrap within Cecr2. Reporter gene expression demonstrated Cecr2 expression to be predominantly neural in the embryo. Mice homozygous for the Cecr2… CONTINUE READING

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