CEACAM1: contact-dependent control of immunity

@article{GrayOwen2006CEACAM1CC,
  title={CEACAM1: contact-dependent control of immunity},
  author={S. Gray-Owen and R. Blumberg},
  journal={Nature Reviews Immunology},
  year={2006},
  volume={6},
  pages={433-446}
}
The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. Recent studies show that there is an important role for members of the CEACAM family in modulating the immune responses associated with infection, inflammation and cancer. In this Review, we consider the evidence for CEACAM involvement… Expand
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433 Citations

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CEACAMs: their role in physiology and pathophysiology
TLDR
Forward and reverse genetics in the mouse now provide powerful novel models to elucidate the action of CEACAM family members in vivo. Expand
CEACAM1 structure and function in immunity and its therapeutic implications.
TLDR
This review examines recent structural information derived from the characterization of CEACAM1 and focuses on interactions and heterophilic modes of binding especially to microbes and how this relates to CEACam1 function. Expand
On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies
TLDR
The literature was reviewed and the various expression patterns of CEACAM1 in different types of tumors were discussed, describing its structure and general biologic functions and emphasizing the most significant findings that link this molecule to poor prognosis. Expand
Signaling by epithelial members of the CEACAM family – mucosal docking sites for pathogenic bacteria
TLDR
A model of signal transduction by CEACAM family members lacking significant cytoplasmic domains is suggested and special emphasis is placed on the functional interplay betweenCEACAMs and integrins that influences matrix adhesion of epithelial cells. Expand
CEACAM1 and the regulation of mucosal inflammation
TLDR
CEACAM1 is primarily an activation-induced cell-surface molecule that functions as a co-inhibitory receptor that results in inhibition of a broad range T-cell functions and represents a new potential therapeutic target in the treatment of IBD. Expand
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis
TLDR
These fascinating proteins illustrate how a better understanding of the CEACAM family of cell adhesion molecules reveals their functional link to the underlying disease and lead to new monitoring and targeting opportunities. Expand
CEA (Carcinoembryonic Antigen) and CEACAM6 (CEA-Related Cell Adhesion Molecul 6) are Expressed in Psoriasis Vulgaris
TLDR
The expression of CEACAMs is related to epidermal cell de-differentiation in the diseased skin of psoriasis vulgaris and is suggested to be related to intracellular-signaling- mediated effects of normal and cancer cells. Expand
The role of CEA-related cell adhesion molecule-1 (CEACAM1) in vascular homeostasis
TLDR
The vascular effects of CEACAM1 are summarized and its role in vascular morphogenesis and endothelial barrier regulation is focused on. Expand
CEACAM1: a key regulator of vascular permeability
TLDR
It is demonstrated that CEACam1 is tyrosine-phosphorylated upon VEGF treatment in a SHP-1- and Src-dependent manner, and that the key residues of the long cytoplasmic domain of CEACAM1 are crucial for CEacAM1 phosphorylation and NO production. Expand
Roles of CEACAM1 in cell communication and signaling of lung cancer and other diseases
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a broadly-expressed immunoglobulin-like cell adhesion molecule with a wide range of biological functions to regulate cell… Expand
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TLDR
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TLDR
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