CEACAM1: contact-dependent control of immunity

  title={CEACAM1: contact-dependent control of immunity},
  author={Scott D. Gray-Owen and Richard S. Blumberg},
  journal={Nature Reviews Immunology},
The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. Recent studies show that there is an important role for members of the CEACAM family in modulating the immune responses associated with infection, inflammation and cancer. In this Review, we consider the evidence for CEACAM involvement… 
CEACAMs: their role in physiology and pathophysiology
On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies
The literature was reviewed and the various expression patterns of CEACAM1 in different types of tumors were discussed, describing its structure and general biologic functions and emphasizing the most significant findings that link this molecule to poor prognosis.
Signaling by epithelial members of the CEACAM family – mucosal docking sites for pathogenic bacteria
A model of signal transduction by CEACAM family members lacking significant cytoplasmic domains is suggested and special emphasis is placed on the functional interplay betweenCEACAMs and integrins that influences matrix adhesion of epithelial cells.
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis
These fascinating proteins illustrate how a better understanding of the CEACAM family of cell adhesion molecules reveals their functional link to the underlying disease and lead to new monitoring and targeting opportunities.
CEACAM1 and the regulation of mucosal inflammation
CEACAM1 is primarily an activation-induced cell-surface molecule that functions as a co-inhibitory receptor that results in inhibition of a broad range T-cell functions and represents a new potential therapeutic target in the treatment of IBD.
CEA (Carcinoembryonic Antigen) and CEACAM6 (CEA-Related Cell Adhesion Molecul 6) are Expressed in Psoriasis Vulgaris
The expression of CEACAMs is related to epidermal cell de-differentiation in the diseased skin of psoriasis vulgaris and is suggested to be related to intracellular-signaling- mediated effects of normal and cancer cells.
The role of CEA-related cell adhesion molecule-1 (CEACAM1) in vascular homeostasis
The vascular effects of CEACAM1 are summarized and its role in vascular morphogenesis and endothelial barrier regulation is focused on.
Roles of CEACAM1 in cell communication and signaling of lung cancer and other diseases
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a broadly-expressed immunoglobulin-like cell adhesion molecule with a wide range of biological functions to regulate cell
CEACAM1: a key regulator of vascular permeability
It is demonstrated that CEACam1 is tyrosine-phosphorylated upon VEGF treatment in a SHP-1- and Src-dependent manner, and that the key residues of the long cytoplasmic domain of CEACAM1 are crucial for CEacAM1 phosphorylation and NO production.


CEA adhesion molecules: multifunctional proteins with signal-regulatory properties.
  • B. Obrink
  • Biology, Chemistry
    Current opinion in cell biology
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Angiogenic properties of the carcinoembryonic antigen-related cell adhesion molecule 1.
Findings indicate that CEACAM1 is an angiogenic factor and an effector of VEGF.
The carcinoembryonic antigen (CEA) modulates effector‐target cell interaction by binding to activated lymphocytes
It is demonstrated that the density of the CEA molecules on the tumor cell surface has a determining influence on its protective function, and suggests that tumor cells can modulate effector cell adhesion by regulating the turnover rate of CEA onThe tumor cell membrane.
The Critical Role of Residues 43R and 44Q of Carcinoembryonic Antigen Cell Adhesion Molecules-1 in the Protection from Killing by Human NK Cells1
It is demonstrated that CEACAM1 interacts withCEACAM5, but not with CEacAM6, and the molecular basis for CEACam1 recognition of various CEAC AM family members is provided.
Activation-Induced Expression of Carcinoembryonic Antigen-Cell Adhesion Molecule 1 Regulates Mouse T Lymphocyte Function1
A role for CEACAM1 is supported as a novel class of immunoreceptor tyrosine-based inhibition motif-bearing regulatory molecules on T cells that are active during early phases of the immune response in mice.
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 on Murine Dendritic Cells Is a Potent Regulator of T Cell Stimulation1
The results show that CEACAM1 is a signal-transducing receptor that can regulate early maturation and activation of DC, thereby facilitating priming and polarization of T cell responses.
CEACAM1 is a potent regulator of B cell receptor complex‐induced activation
It is shown that the CEACAM1 isoform expression pattern is different in nonactivated and activated primary mouse B lymphocytes and that CEACam1 influences B cell receptor complex‐mediated activation and that it is understood that homophilic CEacAM1–CEACAM 1 cell‐mediated binding is the physiological stimulus for CEAC AM1‐triggered B cell signaling.
Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 1 Isoforms Alternatively Inhibit and Costimulate Human T Cell Function1
It is indicated that the long and short cyt tails of CEACAM1 serve as inhibitory and costimulatory receptors, respectively, in T cell regulation.
Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes
It is reported here that N. gonorrhoeae Opa proteins were able to bind CEACAM1 expressed by primary CD4+ T lymphocytes and suppress their activation and proliferation.
B lymphocyte and macrophage expression of carcinoembryonic antigen‐related adhesion molecules that serve as receptors for murine coronavirus
The expression of carcinoembryonic antigen (CEA)‐related glycoproteins that have been associated with intercellular adhesion and that serve as receptors for mouse hepatitis virus (MHV) was analyzed