CE can identify small molecules that selectively target soluble oligomers of amyloid β protein and display antifibrillogenic activity

@article{Colombo2009CECI,
  title={CE can identify small molecules that selectively target soluble oligomers of amyloid $\beta$ protein and display antifibrillogenic activity},
  author={Raffaella Colombo and Angelo Carotti and Marco Catto and Marco Racchi and Cristina Lanni and Laura Verga and Gabriele Caccialanza and Ersilia De Lorenzi},
  journal={ELECTROPHORESIS},
  year={2009},
  volume={30}
}
Soluble and toxic oligomers of amyloid β (Aβ) protein have been identified as the true neurotoxic species involved in Alzheimer's disease and considering them as targets to inhibit Aβ aggregation might have a therapeutic value. We previously set up a CE method that enables the separation and quantification of transient oligomers of Aβ protein‐containing 42 amino acids (Aβ1–42) along the pathway leading to fibrils and we now demonstrate how this method can be successfully applied to examine the… 

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