CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer

@article{Wicking1998CDX2AH,
  title={CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer},
  author={Carol Wicking and Lisa A. Simms and Timothy Evans and Michael Walsh and Kallayanee Chawengsaksophak and Felix Beck and Georgia Chenevix-Trench and Joanne A. Young and Jeremy J Jass and Barbara Leggett and Brandon Wainwright},
  journal={Oncogene},
  year={1998},
  volume={17},
  pages={657-659}
}
The Cdx2 gene is one of three murine homologues of the Drosophila homeobox gene caudal. Mice heterozygous for a null mutation in Cdx2 exhibit a variable phenotype including tail abnormalities, stunted growth and a homeotic shift of vertebrae. Most strikingly, however, 90% of heterozygous mice were reported to develop multiple intestinal adenomatous polyps, most notably in the proximal colon (). These observations led us to propose that mutation of CDX2 may be involved in the genesis of some… CONTINUE READING
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