CDX1 is an important molecular mediator of Barrett's metaplasia.

  title={CDX1 is an important molecular mediator of Barrett's metaplasia.},
  author={Newton A C S Wong and Jenny Wilding and Stephen T. Bartlett and Y Liu and Bryan F. Warren and J. Piris and Nick D. Maynard and Richard Marshall and Walter F. Bodmer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 21},
The molecular pathogenesis of Barrett's metaplasia (BM) of the esophagus is poorly understood. The change to an intestinal phenotype occurs on a background of esophagitis due to refluxing acid and bile. CDX1, an important regulator of normal intestinal development, was studied as a potential key molecule in the pathogenesis of BM. CDX1 mRNA and protein were universally expressed in all samples of BM tested but not in normal esophageal squamous or gastric body epithelia. This tissue-specific… CONTINUE READING


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