CDR3 sequence motifs shared by oligoclonal rheumatoid arthritis synovial T cells. Evidence for an antigen-driven response.

@article{Li1994CDR3SM,
  title={CDR3 sequence motifs shared by oligoclonal rheumatoid arthritis synovial T cells. Evidence for an antigen-driven response.},
  author={Y T Li and G R Sun and Joseph R. Tumang and Mary K Crow and Steven M. Friedman},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={94 6},
  pages={2525-31}
}
T lymphocytes reactive with as yet undefined joint-localized foreign or autoantigens may be important in the pathogenesis of RA. Molecular studies demonstrating skewed T cell antigen receptor (TCR) variable gene usage and selective expansion of particular T cell clones within the synovial compartment support this view. Based on our recent study documenting selective expansion of V beta 17+ T cells in RA, we have pursued the identification of T cells relevant to the disease process, in an… CONTINUE READING

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