CDP‐choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement

@article{avun2004CDPcholineIP,
  title={CDP‐choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement},
  author={Sinan Çavun and Vahide Savci},
  journal={Fundamental \& Clinical Pharmacology},
  year={2004},
  volume={18}
}
  • S. Çavun, V. Savci
  • Published 2004
  • Chemistry, Medicine
  • Fundamental & Clinical Pharmacology
In the present study, we investigated the effect of intracerebroventricular (i.c.v.) administration of cytidine‐5′‐diphosphate (CDP) choline on plasma adrenocorticotropin (ACTH), serum growth hormone (GH), thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels in conscious rats. The involvement of cholinergic mechanisms in these effects was also determined. In basal conditions, CDP‐choline (0.5, 1.0 and 2.0 μmol, i.c.v.) increased plasma ACTH… Expand
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In conclusion, intracerebroventricularly injected CDP‐choline can increase plasma vasopressin levels by activating central nicotinic cholinergic receptors through the activation of presynaptic Cholinergic mechanisms. Expand
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