CDP‐choline: Neuroprotection in transient forebrain ischemia of gerbils

@article{Rao1999CDPcholineNI,
  title={CDP‐choline: Neuroprotection in transient forebrain ischemia of gerbils},
  author={Adibhatla Muralikrishna Rao and James Franklin Hatcher and Robert J. Dempsey},
  journal={Journal of Neuroscience Research},
  year={1999},
  volume={58}
}
CDP‐choline is a rate‐limiting intermediate in the biosynthesis of phosphatidylcholine (PtdCho), an important component of the neural cell membrane. The ability of CDP‐choline to alter phospholipid metabolism is an important function in the treatment of ischemic injury. Exogenous treatment with CDP‐choline stimulates PtdCho synthesis and prevents release of free fatty acids (FFA), especially arachidonic acid (AA), after ischemia/reperfusion. Phase III clinical trials of CDP‐choline in the… Expand
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