CDKNA2A mutation analysis, protein expression, and deletion mapping of chromosome 9p in conventional clear-cell renal carcinomas: evidence for a second tumor suppressor gene proximal to CDKN2A.

@article{Schraml2001CDKNA2AMA,
  title={CDKNA2A mutation analysis, protein expression, and deletion mapping of chromosome 9p in conventional clear-cell renal carcinomas: evidence for a second tumor suppressor gene proximal to CDKN2A.},
  author={Peter Schraml and Kirsten Struckmann and Renate Bednar and Weili Fu and T. Christian Gasser and Kim A Wilber and Juha Kononen and Guido Sauter and Michael J{\"o}rg Mihatsch and Holger Moch},
  journal={The American journal of pathology},
  year={2001},
  volume={158 2},
  pages={593-601}
}
Inactivation of tumor suppressor genes on chromosome 9p is considered a critical event in renal cell carcinoma pathogenesis. Alterations of CDKN2A on 9p21 have been reported in renal cancer cell lines, but their relevance for primary renal carcinomas is unclear. Loss of heterozygosity (LOH) was analyzed by using four polymorphic microsatellites at D9S970 (9p12-9p13), D9S171 (9p13), D9S1748 (9p21), and D9S156 (9p21) in 113 primary conventional clear-cell renal cell carcinomas (CRCCs). Allelic… CONTINUE READING

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