CDKN2B expression in adipose tissue of familial combined hyperlipidemia patients.

@article{Horswell2013CDKN2BEI,
  title={CDKN2B expression in adipose tissue of familial combined hyperlipidemia patients.},
  author={Stuart D Horswell and Lee G. D. Fryer and Claire E. Hutchison and Dlear Zindrou and Helen E. Speedy and Margaret-M Town and Emma J. Duncan and Rasheeta Sivapackianathan and Hetal N. Patel and Emma Jones and Adam T. Braithwaite and Max P A Salm and Claire K Y Neuwirth and Elizabeth M Potter and Jonathan R. Anderson and K. M. Taylor and Mary Seed and David John Betteridge and M. A. Crook and Anthony S Wierzbicki and James M Scott and Rossitza P. Naoumova and Carol C. Shoulders},
  journal={Journal of lipid research},
  year={2013},
  volume={54 12},
  pages={3491-505}
}
The purpose of this study was to determine the core biological processes perturbed in the subcutaneous adipose tissue of familial combined hyperlipidemia (FCHL) patients. Annotation of FCHL and control microarray datasets revealed a distinctive FCHL transcriptome, characterized by gene expression changes regulating five overlapping systems: the cytoskeleton, cell adhesion and extracellular matrix; vesicular trafficking; lipid homeostasis; and cell cycle and apoptosis. Expression values for the… CONTINUE READING
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