CDKN2A mutations in multiple primary melanomas.

  title={CDKN2A mutations in multiple primary melanomas.},
  author={Jose Monzon and Ling Liu and Herbert Brill and Alisa M Goldstein and Margaret A. Tucker and Lynn From and John McLaughlin and David Hogg and Norman J. Lassam},
  journal={The New England journal of medicine},
  volume={338 13},
BACKGROUND Germ-line mutations in the CDKN2A tumor-suppressor gene (also known as p16, p16INK4a, and MTS1) have been linked to the development of melanoma in some families with inherited melanoma. Whether mutations in CDKN2A confer a predisposition to sporadic (nonfamilial) melanoma is not known. In some patients with sporadic melanoma, one or more additional primary lesions develop, suggesting that some of these patients have an underlying genetic susceptibility to the cancer. We hypothesized… CONTINUE READING


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