CDKN2A/p16 inactivation is related to pituitary adenoma type and size.

  title={CDKN2A/p16 inactivation is related to pituitary adenoma type and size.},
  author={Nadine Seemann and Dorothee Kuhn and Christian Wrocklage and Kathy Keyvani and Wolfgang Hackl and Michael Buchfelder and Rudolf Fahlbusch and W. Paulus},
  journal={The Journal of pathology},
  volume={193 4},
p16 (CDKN2A, MTS1, INK4A) status at genomic and protein levels was analysed and correlated with clinico-pathological features in 72 pituitary adenomas. Methylation of CpG islands of promoter/exon 1 sequences was found in most gonadotroph, lactotroph, plurihormonal, and null cell adenomas (36 of 44, 82%), but it was rare in somatotroph (1 of 13 cases, 8%) and corticotroph adenomas (1 of 15 cases, 7%). Homozygous CDKN2A deletion was restricted to rare somatotroph (15%) and corticotroph adenomas… CONTINUE READING
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