CDKN2A, CDKN2B and p14ARF are frequently and differentially methylated in ependymal tumours.

@article{Rousseau2003CDKN2ACA,
  title={CDKN2A, CDKN2B and p14ARF are frequently and differentially methylated in ependymal tumours.},
  author={Emmanuel Rousseau and M Ruchoux and Francesco Scaravilli and Françoise Chapon and Mathieu Vinchon and Charles de Smet and Catherine Godfraind and Miikka Vikkula},
  journal={Neuropathology and applied neurobiology},
  year={2003},
  volume={29 6},
  pages={574-83}
}
Ependymal tumours are histologically and clinically varied lesions. Numerical abnormalities of chromosome 9 are frequently associated with these tumours. Nevertheless, the three important tumour suppressor genes located in this chromosome, CDKN2A, CDKN2B and p14 ARF, have not been reported to be commonly altered in them. We studied promoter methylation of these genes, an important mechanism associated with gene silencing in a series of 152 ependymal tumours of WHO grades I to III. Methylation… CONTINUE READING
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