CDKN 2 A Common Variants and Their Association with Melanoma Risk : A Population-Based Study

@inproceedings{Dbniak2005CDKN2A,
  title={CDKN 2 A Common Variants and Their Association with Melanoma Risk : A Population-Based Study},
  author={Tadeusz Dębniak and Rodney J. Scott and Tomasz Huzarski and Tomasz Byrski and Andrzej Rozmiarek and Bogusław Dȩbniak and Elżbieta Załuga and Romuald Maleszka and J{\'o}zef Kładny and Bohdan G{\'o}rski and Cezary Cybulski and Jacek Gronwald and Grzegorz Kurzawski and Jan Lubiński},
  year={2005}
}
The population frequencies of the CDKN2A variants remain undetermined. In Poland there are three common variants of CDKN2A : an alanine to threonine substitution (A148T), Nt500c>g and Nt540c>t, which have been detected in other populations. To establish if they are associated with an increased malignant melanoma (MM) risk we did an association study based on genotyping 471 patients with MMand 1,210 random control subjects from the same Polish population. We found a significantly increased… CONTINUE READING

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