CDKL5 regulates flagellar length and localizes to the base of the flagella in Chlamydomonas

@inproceedings{Tam2013CDKL5RF,
  title={CDKL5 regulates flagellar length and localizes to the base of the flagella in Chlamydomonas},
  author={Lai-wa Tam and Paul T. Ranum and Paul A Lefebvre},
  booktitle={Molecular biology of the cell},
  year={2013}
}
The length of Chlamydomonas flagella is tightly regulated. Mutations in four genes-LF1, LF2, LF3, and LF4-cause cells to assemble flagella up to three times wild-type length. LF2 and LF4 encode protein kinases. Here we describe a new gene, LF5, in which null mutations cause cells to assemble flagella of excess length. The LF5 gene encodes a protein kinase… CONTINUE READING