CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail.

@article{Rusconi2008CDKL5EI,
  title={CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail.},
  author={Laura Rusconi and Lisa Salvatoni and Laura Giudici and Ilaria Bertani and Charlotte Kilstrup-Nielsen and Vania Broccoli and Nicoletta Landsberger},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 44},
  pages={30101-11}
}
Mutations in the human X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in patients with Rett syndrome (RTT), West syndrome, and X-linked infantile spasms, sharing the common feature of mental retardation and early seizures. CDKL5 is a rather uncharacterized kinase, but its involvement in RTT seems to be explained by the fact that it works upstream of MeCP2, the main cause of Rett syndrome. To understand the role of this kinase for nervous system functions and to… CONTINUE READING
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Modulation of CDKL5 Expression during Neuronal Development 30110 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • F. Mari, S. Azimonti, +12 authors unpublished results
  • Mol. Genet
  • 2008

Modulation of CDKL5 Expression during Neuronal Development

  • Mol. Genet
  • OCTOBER 31,
  • 2005

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