CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons

@inproceedings{Ricciardi2012CDKL5EE,
  title={CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons},
  author={Sara Ricciardi and Federica Ungaro and Melanie Hambrock and Nils Rademacher and Gilda Stefanelli and Dario Brambilla and Alessandro Sessa and Cinzia Magagnotti and Angela Bachi and Elisa Giarda and Chiara Verpelli and Charlotte Kilstrup-Nielsen and Carlo Sala and Vera M. Kalscheuer and Vania Broccoli},
  booktitle={Nature Cell Biology},
  year={2012}
}
Mutations of the cyclin-dependent kinase-like 5 (CDKL5) and netrin-G1 (NTNG1) genes cause a severe neurodevelopmental disorder with clinical features that are closely related to Rett syndrome, including intellectual disability, early-onset intractable epilepsy and autism. We report here that CDKL5 is localized at excitatory synapses and contributes to correct dendritic spine structure and synapse activity. To exert this role, CDKL5 binds and phosphorylates the cell adhesion molecule NGL-1. This… CONTINUE READING
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