CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.

@article{Spruijt2010CDK2AP1DOC1IA,
  title={CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.},
  author={Cornelia G. Spruijt and Stefanie J. J. Bartels and Arie B Brinkman and Jorrit V Tjeertes and Ina Poser and Hendrik G. Stunnenberg and Michiel Vermeulen},
  journal={Molecular bioSystems},
  year={2010},
  volume={6 9},
  pages={
          1700-6
        }
}
The Mi-2/NuRD (NUcleosome Remodeling and histone Deacetylase) chromatin remodeling complex is a large heterogeneous multiprotein complex associated with transcriptional repression. Here we apply a SILAC based quantitative proteomics approach to show that all known Mi-2/NuRD complex subunits co-purify with Cyclin Dependent Kinase 2 Associated Protein1 (CDK2AP1), also known as Deleted in Oral Cancer 1 (DOC-1). DOC-1 displays in vitro binding affinity for methylated DNA as part of the meCpG… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS