CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage.

  title={CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage.},
  author={Haojie Huang and Kevin Regan and Zhenkun Lou and Junjie Chen and Donald J. Tindall},
  volume={314 5797},
The function of cyclin-dependent kinase 2 (CDK2) is often abolished after DNA damage. The inhibition of CDK2 plays a central role in DNA damage-induced cell cycle arrest and DNA repair. However, whether CDK2 also influences the survival of cells under genotoxic stress is unknown. Forkhead box O (FOXO) transcription factors are emerging as key regulators of cell survival. CDK2 specifically phosphorylated FOXO1 at serine-249 (Ser249) in vitro and in vivo. Phosphorylation of Ser249 resulted in… CONTINUE READING
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