CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation

@inproceedings{Shuda2015CDK1SF,
  title={CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation},
  author={Masahiro Shuda and Celestino Vel{\'a}squez and Erdong Cheng and Daniel G. Cordek and Hyun Jin Kwun and Yuan - Chia Chang Yeun - Chung Chang Chin - Chen Chang and Patrick S Moore},
  booktitle={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015}
}
Mitosis is commonly thought to be associated with reduced cap-dependent protein translation. Here we show an alternative control mechanism for maintaining cap-dependent translation during mitosis revealed by a viral oncoprotein, Merkel cell polyomavirus small T (MCV sT). We find MCV sT to be a promiscuous E3 ligase inhibitor targeting the anaphase-promoting complex, which increases cell mitogenesis. MCV sT binds through its Large T stabilization domain region to cell division cycle protein 20… CONTINUE READING

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