CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation

@inproceedings{Huskey2015CDK1IT,
  title={CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation},
  author={Noelle E. Huskey and Tingxia Guo and Kimberley J. Evason and Olga Momcilovic and David M Pardo and Katelyn J. Creasman and Robert L Judson and Robert Blelloch and Scott A. Oakes and Matthias Hebrok and Andrei Goga},
  booktitle={Stem cell reports},
  year={2015}
}
Embryonic stem cells (ESCs) have adopted an accelerated cell-cycle program with shortened gap phases and precocious expression of cell-cycle regulatory proteins, including cyclins and cyclin-dependent kinases (CDKs). We examined the effect of CDK inhibition on the pathways regulating proliferation and survival of ESCs. We found that inhibiting cyclin-dependent kinase 1 (CDK1) leads to activation of the DNA damage response, nuclear p53 stabilization, activation of a subset of p53 target genes… CONTINUE READING

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