CDK inhibitor enhances the sensitivity to 5-fluorouracil in colorectal cancer cells.

@article{Takagi2008CDKIE,
  title={CDK inhibitor enhances the sensitivity to 5-fluorouracil in colorectal cancer cells.},
  author={Koichi Takagi and Yoshihiro Sowa and Ozgur Muhammer Cevik and Ryoko Nakanishi and Toshiyuki Sakai},
  journal={International journal of oncology},
  year={2008},
  volume={32 5},
  pages={1105-10}
}
Thymidylate synthase (TS) is a dNTP synthetic enzyme and is also a target enzyme of 5-fluorouracil (5-FU). 5-FU is one of the anticancer agents most frequently used for the treatment of colorectal cancers. However, the clinical rate of response to its use as a single agent is not exceptionally high. Therefore, various combination chemotherapies have been devised. The elevated expression of TS in cancer cells is a serious obstacle in the clinical use of 5-FU. In the present study, TS expression… CONTINUE READING