CDK activity provides temporal and quantitative cues for organizing genome duplication

Abstract

In eukaryotes, the spatial and temporal organization of genome duplication gives rise to distinctive profiles of replication origin usage along the chromosomes. While it has become increasingly clear that these programs are important for cellular physiology, the mechanisms by which they are determined and modulated remain elusive. Replication initiation… (More)
DOI: 10.1371/journal.pgen.1007214

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