CDK Substrate Phosphorylation and Ordering the Cell Cycle

  title={CDK Substrate Phosphorylation and Ordering the Cell Cycle},
  author={Matthew P. Swaffer and Andrew E. W. Jones and Helen R Flynn and Ambrosius P Snijders and Paul Nurse},
S phase and mitotic onset are brought about by the action of multiple different cyclin-CDK complexes. However, it has been suggested that changes in the total level of CDK kinase activity, rather than substrate specificity, drive the temporal ordering of S phase and mitosis. Here, we present a phosphoproteomics-based systems analysis of CDK substrates in fission yeast and demonstrate that the phosphorylation of different CDK substrates can be temporally ordered during the cell cycle by a single… CONTINUE READING
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