CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication

@article{Mansilla2020CDKIndependentAP,
  title={CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication},
  author={Sabrina Florencia Mansilla and Mar{\'i}a Bel{\'e}n de la Vega and Nicol{\'a}s Luis Calzetta and Sebasti{\'a}n Omar Siri and Vanesa Gottifredi},
  journal={Genes},
  year={2020},
  volume={11}
}
p21Waf/CIP1 is a small unstructured protein that binds and inactivates cyclin-dependent kinases (CDKs). To this end, p21 levels increase following the activation of the p53 tumor suppressor. CDK inhibition by p21 triggers cell-cycle arrest in the G1 and G2 phases of the cell cycle. In the absence of exogenous insults causing replication stress, only residual p21 levels are prevalent that are insufficient to inhibit CDKs. However, research from different laboratories has demonstrated that these… Expand
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