CDK-1 inhibits meiotic spindle shortening and dynein-dependent spindle rotation in C. elegans

@inproceedings{Ellefson2011CDK1IM,
  title={CDK-1 inhibits meiotic spindle shortening and dynein-dependent spindle rotation in C. elegans},
  author={Marina L. Ellefson and Francis J McNally},
  booktitle={The Journal of cell biology},
  year={2011}
}
In animals, the female meiotic spindle is positioned at the egg cortex in a perpendicular orientation to facilitate the disposal of half of the chromosomes into a polar body. In Caenorhabditis elegans, the metaphase spindle lies parallel to the cortex, dynein is dispersed on the spindle, and the dynein activators ASPM-1 and LIN-5 are concentrated at spindle poles. Anaphase-promoting complex (APC) activation results in dynein accumulation at spindle poles and dynein-dependent rotation of one… CONTINUE READING
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