CDH4 as a novel putative tumor suppressor gene epigenetically silenced by promoter hypermethylation in nasopharyngeal carcinoma.

@article{Du2011CDH4AA,
  title={CDH4 as a novel putative tumor suppressor gene epigenetically silenced by promoter hypermethylation in nasopharyngeal carcinoma.},
  author={Chunping Du and Tingting Huang and Di Sun and Yingxi Mo and Haiyan Feng and Xiaoying Zhou and Xue Xiao and Nana Yu and Bo Hou and Guangwu Huang and Ingemar Ernberg and Zhe Zhang},
  journal={Cancer letters},
  year={2011},
  volume={309 1},
  pages={54-61}
}
We investigated the transcription levels, promoter methylation status and role as a tumor suppressor gene (TSG) of the cadherin CDH4 in nasopharyngeal carcinoma (NPC). The expression of CDH4 was decreased in NPC cell lines, xenografts and primary tumor biopsies. Promoter hypermethylation of CDH4 was detected in all five NPC cell lines, both NPC xenograft lines and 94.3% of primary tumors but not in any of the 12 normal epithelial samples. Loss of CDH4 expression could be restored by the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Atrazine exposure elicits copy number alterations in the zebrafish genome.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP • 2017

Study on expression of CDH4 in lung cancer

World journal of surgical oncology • 2017
View 1 Excerpt

Similar Papers

Loading similar papers…