CDH17 Is a More Sensitive Marker for Gastric Adenocarcinoma Than CK20 and CDX2.

@article{AltreeTacha2017CDH17IA,
  title={CDH17 Is a More Sensitive Marker for Gastric Adenocarcinoma Than CK20 and CDX2.},
  author={David Altree-Tacha and Jillian Tyrrell and Thomas Haas},
  journal={Archives of pathology & laboratory medicine},
  year={2017},
  volume={141 1},
  pages={144-150}
}
CONTEXT -CDH17, which is expressed in the intestinal epithelium, is a novel oncogene involved in tumor invasion and metastasis. A panel consisting of cytokeratin (CK) 7, CD20, and CDX2 antibodies is typically used to diagnose gastrointestinal adenocarcinomas. However, studies have shown that CDH17 is a highly specific marker for gastrointestinal adenocarcinoma and may be important in clinical diagnosis. OBJECTIVE -To evaluate the sensitivity and specificity of CDH17, CK20, and CDX2 antibodies… CONTINUE READING